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Article

High frequency of ultraviolet mutations at the INK4a-ARF locus in squamous cell carcinomas from psoralen-plus-ultraviolet-A-treated psoriasis patients.

The Journal of investigative dermatology - 1 Apr 2003

Kreimer-Erlacher Heidemarie, Seidl Hannes, Bäck Barbara, Cerroni Lorenzo, Kerl Helmut, Wolf Peter

Abstract excerpt

Squamous cell carcinomas in psoralen-plus-ultraviolet A (PUVA) treated patients frequently exhibit p53 tumor suppressor genes and Ha-ras protooncogenes that are mutated at dipyrimidine sites and carry the ultraviolet fingerprint (i.e., C-to-T or CC-to-TT transitions). To further broaden the knowledge of genetic mutations in PUVA-associated skin cancer, we used DNA sequencing analysis to study the mutational...

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Share to Carcinoma, Squamous Cell
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Fingerprinting

Share to Photosensitizing Agents

Share to Polymorphism, Single-Stranded Conformational

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Share to Tumor Suppressor Protein p14ARF

Source

Identifiers

PMID: 12648234
DOI: 10.1046/j.1523-1747.2003.12085.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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High frequency of ultraviolet mutations at the INK4a-ARF locus in squamous cell carcinomas from psoralen-plus-ultraviolet-A-treated psoriasis patients.PMID 12648234Read ↗

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