Article
Use of single nucleotide polymorphism arrays to identify a novel region of loss on chromosome 6q in squamous cell carcinomas of the oral cavity.
Head & neck - 1 Apr 2004
Tong Betty C, Dhir Karan, Ha Patrick K, Westra William H, Alter Blanche P, Sidransky David, Koch Wayne M, Califano Joseph A
Abstract excerpt
BACKGROUND: A subset of patients with oral cavity squamous cell carcinoma(SCC), often of young age yet lacking a history of carcinogen exposure, has been identified, with no clear etiology for tumor development. METHODS: To identify somatic genetic alterations unique to this patient population, we performed a high throughput single nucleotide polymorphism (SNP) analysis, quantitative PCR of the E6 and E7 regions...
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