Article
Head and neck cancer in young adults and nonsmokers: study of cancer susceptibility by genome-wide high-density SNP microarray mapping.
Acta oto-laryngologica - 1 Oct 2011
Pfeiffer Jens, Wiech Thorsten, Maier Wolfgang, Ridder Gerd J, Laszig Roland, Birkenhäger Ralf
Abstract excerpt
CONCLUSION: Our results raise the question as to whether specific patterns of 'germline loss of heterozygosity (LOH)' could contribute to the genetic susceptibility for head and neck squamous cell carcinoma (HNSCC). OBJECTIVES: HNSCC usually occurs in older individuals with a history of smoking. However, about 5% of HNSCC patients have never used tobacco or develop this disease at an exceptionally young age....
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