Article
A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion.
Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 2004
Xu Hongzhan, Svarovskaia Evguenia S, Barr Rebekah, Zhang Yijun, Khan Mohammad A, Strebel Klaus, Pathak Vinay K
Abstract excerpt
HIV-1 and other retroviruses occasionally undergo hypermutation, characterized by a high rate of G-to-A substitution. Recently, the human apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G (APOBEC3G), first identified as CEM15, was shown to be packaged into retroviral virions and to deaminate deoxycytidine to deoxyuridine in newly synthesized viral minus-strand DNA, thereby inducing G-to-A...
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