The elimination of diazepam in Chinese subjects is dependent on the mephenytoin oxidation phenotype.

doi:10.1046/j.1365-2125.1996.42712.x

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Article

The elimination of diazepam in Chinese subjects is dependent on the mephenytoin oxidation phenotype.

British journal of clinical pharmacology - 1 Oct 1996

Wan J, Xia H, He N, Lu Y Q, Zhou H H

Abstract excerpt

1. The disposition of diazepam and desmethyldiazepam was studied in 21 healthy male Chinese subjects who were phenotyped with mephenytoin. Four poor metabolizers (PM) were identified by phenotyping with mephenytoin and by genotyping for CYP2C19. 2. Serum diazepam and desmethyldiazepam concentrati...

Topics

Asian People
China
Chromatography, High Pressure Liquid
Diazepam
Genotype
Half-Life
Humans
Hydroxylation
Male
Mephenytoin
Oxidation-Reduction
Phenotype
Polymorphism, Genetic

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