Article
Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set.
Molecular microbiology - 1 Apr 2004
Sun Ronggai, Converse Paul J, Ko Chiew, Tyagi Sandeep, Morrison Norman E, Bishai William R
Abstract excerpt
Bacterial alternative RNA polymerase sigma factors are key global adaptive response regulators with a likely role in Mycobacterium tuberculosis pathogenesis. We constructed a mutant lacking the sigma factor gene, sigC, by allelic exchange, in the virulent CDC1551 strain of M. tuberculosis and compared the resulting mutant with the isogenic wild-type strain and complemented mutant strain. In vitro, compared to the...
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