Reduced immunopathology and mortality despite tissue persistence in a <i>Mycobacterium tuberculosis</i> mutant lacking alternative σ factor, SigH

Abstract excerpt

The pathogenesis of tuberculosis involves multiple phases and is believed to involve both a carefully deployed series of adaptive bacterial virulence factors and inappropriate host immune responses that lead to tissue damage. A defined Mycobacterium tuberculosis mutant strain lacking the sigH-encoded transcription factor showed a distinctive infection phenotype. In resistant C57BL/6 mice, the mutant achieved high...

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