Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The unique N-terminal region of Mycobacterium tuberculosis sigma factor A plays a dominant role in the essential function of this protein

20 Jan 2023

Abstract excerpt

SigA (σ A ) is an essential protein and the primary sigma factor in Mycobacterium tuberculosis ( Mtb ). However, due to the absence of genetic tools, our understanding of the role and regulation of σ A activity and its molecular attributes that help modulate Mtb survival is scant. Here, we generated a conditional gene replacement of σ A in Mtb and showed that its depletion results in a severe survival defect in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotic Resistance in Bacteria
Share to Mycobacterium research and diagnosis
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36690275
DOI: 10.1016/j.jbc.2023.102933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The unique N-terminal region of Mycobacterium tuberculosis sigma factor A plays a dominant role in the essential function of this proteinPMID 36690275Read ↗

Mycobacterium tuberculosis RNA polymerase-binding protein A (RbpA) and its interactions with sigma factors.Semantic proximity Read ↗

Domains within RbpA Serve Specific Functional Roles That Regulate the Expression of Distinct Mycobacterial Gene SubsetsSemantic proximity Read ↗

The σ factors of<i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Physiological Roles of an <i>Acinetobacter</i> -specific σ FactorSemantic proximity Read ↗

Sigma Factors: Key Molecules in <i>Mycobacterium tuberculosis</i> Physiology and VirulenceSemantic proximity Read ↗

Structure of a Wbl protein and implications for NO sensing by M. tuberculosisSemantic proximity Read ↗

A Role for Sigma Factor σE in Corynebacterium pseudotuberculosis Resistance to Nitric Oxide/Peroxide StressSemantic proximity Read ↗

The Mycobacterium tuberculosis sigma factor sigmaB is required for full response to cell envelope stress and hypoxia in vitro, but it is dispensable for in vivo growth.Semantic proximity Read ↗

Transposon mutagenesis in Mycobacterium abscessus identifies an essential penicillin-binding protein involved in septal peptidoglycan synthesis and antibiotic sensitivitySemantic proximity Read ↗

Structure-aware <i>M. tuberculosis</i> functional annotation uncloaks resistance, metabolic, and virulence genesSemantic proximity Read ↗

High-density transposon mutagenesis in <i>Mycobacterium abscessus</i> identifies an essential penicillin-binding lipo-protein (PBP-lipo) involved in septal peptidoglycan synthesis and antibiotic sensitivitySemantic proximity Read ↗

MtrA regulation of essential peptidoglycan cleavage in <i>Mycobacterium tuberculosis</i> during infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.