The Mycobacterium tuberculosis extracytoplasmic-function sigma factor SigL regulates polyketide synthases and secreted or membrane proteins and is required for virulence.

Abstract excerpt

Mycobacterium tuberculosis sigL encodes an extracytoplasmic function (ECF) sigma factor and is adjacent to a gene for a membrane protein (Rv0736) that contains a conserved HXXXCXXC sequence. This motif is found in anti-sigma factors that regulate several ECF sigma factors, including those that co...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Expression Regulation, Bacterial
• Share to Macrolides
• Share to Mice, Inbred BALB C