Activation of the eis gene in a W-Beijing strain of Mycobacterium tuberculosis correlates with increased SigA levels and enhanced intracellular growth

Abstract excerpt

There is growing evidence that strains of Mycobacterium tuberculosis differ in pathogenicity and transmissibility, but little is understood about the contributory factors. We have previously shown that increased expression of the principal sigma factor, SigA, mediates the capacity of M. tuberculosis strain 210 to grow more rapidly in human monocytes, compared with other strains. Strain 210 is part of the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Diagnosis and treatment of tuberculosis
• Share to Mycobacterium research and diagnosis
• Share to Tuberculosis Research and Epidemiology