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Article

A Role for Mycobacterium tuberculosis Sigma Factor C in Copper Nutritional Immunity.

International journal of molecular sciences - 20 Feb 2021

Grosse-Siestrup Benjamin T, Gupta Tuhina, Helms Shelly, Tucker Samantha L, Voskuil Martin I, Quinn Frederick D, Karls Russell K

Abstract excerpt

Sigma factor C (SigC) contributes to Mycobacterium tuberculosis virulence in various animal models, but the stress response coordinated by this transcription factor was undefined. The results presented here indicate that SigC prevents copper starvation. Whole genome expression studies demonstrate short-term (4-h) induction of sigC, controlled from a tetracycline-inducible promoter, upregulates ctpB and genes in...

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Identifiers

PMID: 33672733
DOI: 10.3390/ijms22042118
PMCID: PMC7924339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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