MRE11-deficiency associated with improved long-term disease free survival and overall survival in a subset of stage III colon cancer patients in randomized CALGB 89803 trial.

doi:10.1371/journal.pone.0108483

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Article

MRE11-deficiency associated with improved long-term disease free survival and overall survival in a subset of stage III colon cancer patients in randomized CALGB 89803 trial.

PloS one - 1 Jan 2014

Pavelitz Thomas, Renfro Lindsay, Foster Nathan R, Caracol Amber, Welsch Piri, Lao Victoria Valinluck, Grady William B, Niedzwiecki Donna, Saltz Leonard B, Bertagnolli Monica M, Goldberg Richard M, Rabinovitch Peter S, Emond Mary, Monnat Raymond J, Maizels Nancy

Abstract excerpt

PURPOSE: Colon cancers deficient in mismatch repair (MMR) may exhibit diminished expression of the DNA repair gene, MRE11, as a consequence of contraction of a T11 mononucleotide tract. This study investigated MRE11 status and its association with prognosis, survival and drug response in patients with stage III colon cancer. PATIENTS AND METHODS: Cancer and Leukemia Group B 89803 (Alliance) randomly assigned...

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PMID: 25310185
DOI: 10.1371/journal.pone.0108483
PMCID: PMC4195600

Genes

MRE11

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