Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

The MRE11/RAD50/NBS1 complex destabilization in Lynch-syndrome patients.

European journal of human genetics : EJHG - 1 Sept 2007

Alemayehu Aster, Fridrichova Ivana

Abstract excerpt

Lynch syndrome is an inherited disease leading to the development predominantly of colorectal cancer (CRC). The crucial cause is malfunction of DNA mismatch repair that is characterized by high level of microsatellite instability; however, new knowledge of two MSI modes (types A and B) suggests a more complex molecular basis of this syndrome. To investigate, whether the extensive alterations in individual MSI...

Topics

Acid Anhydride Hydrolases
Adult
Cell Cycle Proteins
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Breaks, Double-Stranded
DNA Mismatch Repair
DNA Repair Enzymes
DNA, Neoplasm
DNA-Binding Proteins
Humans
MRE11 Homologue Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsatellite Instability

Mutation

Nuclear Proteins

Source

Identifiers

PMID: 17534377
DOI: 10.1038/sj.ejhg.5201858

Genes

MRE11
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The MRE11/RAD50/NBS1 complex destabilization in Lynch-syndrome patients.PMID 17534377Read ↗

MRN (MRE11-RAD50-NBS1) Complex in Human Cancer and Prognostic Implications in Colorectal CancerSemantic proximity Read ↗

Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability.Semantic proximity Read ↗

Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.Semantic proximity Read ↗

MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatmentSemantic proximity Read ↗

A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex.Semantic proximity Read ↗

Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN ComplexSemantic proximity Read ↗

Mutation Spectra of the MRN (MRE11, RAD50, NBS1/NBN) Break Sensor in Cancer CellsSemantic proximity Read ↗

Microsatellite Instability and Aberrant Pre-mRNA Splicing: How Intimate Is It?Semantic proximity Read ↗

Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability.Semantic proximity Read ↗

The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer.Semantic proximity Read ↗

MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.Semantic proximity Read ↗

A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.