Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number.

doi:10.1111/j.1600-0854.2012.01343.x

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Article

Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number.

Traffic (Copenhagen, Denmark) - 1 May 2012

Storrie Brian, Micaroni Massimo, Morgan Garry P, Jones Nick, Kamykowski Jeffrey A, Wilkins Ngozi, Pan Timothy H, Marsh Brad J

Abstract excerpt

We have shown previously that Rab6, a small, trans-Golgi-localized GTPase, acts upstream of the conserved oligomeric Golgi complex (COG) and ZW10/RINT1 retrograde tether complexes to maintain Golgi homeostasis. In this article, we present evidence from the unbiased and high-resolution approach of...

Topics

Biological Transport
COP-Coated Vesicles
Electron Microscope Tomography
Golgi Apparatus
Green Fluorescent Proteins
HeLa Cells
Homeostasis
Humans
Image Processing, Computer-Assisted
Microscopy, Electron
Myosin Type II
Phenotype
Protein Isoforms

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Transport

RNA, Small Interfering

rab GTP-Binding Proteins

trans-Golgi Network

Source

Open in PubMed Open full text

Identifiers

PMID: 22335553
DOI: 10.1111/j.1600-0854.2012.01343.x
PMCID: PMC3324626

Genes

RINT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-22335553-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.