A Rab1 mutant affecting guanine nucleotide exchange promotes disassembly of the Golgi apparatus.

doi:10.1083/jcb.125.3.557

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Article

A Rab1 mutant affecting guanine nucleotide exchange promotes disassembly of the Golgi apparatus.

The Journal of cell biology - 1 May 1994

Wilson B S, Nuoffer C, Meinkoth J L, McCaffery M, Feramisco J R, Balch W E, Farquhar M G

Abstract excerpt

The Golgi apparatus is a dynamic organelle whose structure is sensitive to vesicular traffic and to cell cycle control. We have examined the potential role for rab1a, a GTPase previously associated with ER to Golgi and intra-Golgi transport, in the formation and maintenance of Golgi structure. Bacterially expressed, recombinant rab1a protein was microinjected into rat embryonic fibroblasts, followed by analysis...

Topics

Animals
Brefeldin A
Cells, Cultured
Coatomer Protein
Cyclopentanes
GTP Phosphohydrolases
GTP-Binding Proteins
Golgi Apparatus
In Vitro Techniques
Mannosidases
Microinjections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Electron

Microtubule-Associated Proteins

Mutation

Rats

Recombinant Proteins

rab1 GTP-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 8175881
DOI: 10.1083/jcb.125.3.557
PMCID: PMC2119990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8175881-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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