Article
Lipid-interacting properties of the N-terminal domain of human apolipoprotein C-III.
Protein engineering - 1 Jun 2002
Lins L, Flore C, Chapelle L, Talmud P J, Thomas A, Brasseur R
Abstract excerpt
The lipid-interacting properties of the N-terminal domain of human apolipoprotein C-III (apo C-III) were investigated. By molecular modeling, we predicted that the 6-20 fragment of apo C-III is obliquely orientated at the lipid/water interface owing to an asymmetric distribution of the hydrophobic residues when helical. This is characteristic of 'tilted peptides' originally discovered in viral fusion proteins and...
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