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Oligonucleotide ligation assay-based DNA chip for multiplex detection of single nucleotide polymorphism.

Biosensors & bioelectronics - 15 May 2004

Deng Jiao-Yu, Zhang Xian-En, Mang Yuan, Zhang Zhi-Ping, Zhou Ya-Feng, Liu Qiang, Lu Hong-Bing, Fu Zhi-Jun

Abstract excerpt

An oligonucleotide ligation assay-based DNA chip has been developed to detect single nucleotide polymorphism. Synthesized nonamers, complementary to the flanking sequences of the mutation sites in target DNA, were immobilized onto glass slides through disulfide bonds on their 5' terminus. Allele-specific pentamers annealed adjacent to the nonamers on the complementary target DNA, containing 5'-phosphate groups...

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PMID: 15046760
DOI: 10.1016/j.bios.2003.11.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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