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Article

High-throughput ultra-sensitive discrimination of single nucleotide polymorphism via click chemical ligation.

The Analyst - 16 Dec 2019

Zhou Qian-Yu, Zhong Xin-Ying, Zhao Ling-Li, Wang Li-Juan, Zhou Ying-Lin, Zhang Xin-Xiang

Abstract excerpt

Single nucleotide polymorphisms (SNPs) have been proven to be important biomarkers for disease diagnosis, prognosis and disease pathogenesis. Here, taking the advantages of a self-assembled oligonucleotide sandwich structure and robust chemical reactions, we have developed a simple, high-throughput and effective colorimetric analytical technique termed CuAAC-based ligation-assisted assays (CuAAC-LA) for SNP...

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PMID: 31724655
DOI: 10.1039/c9an01672d

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