Article
Different states of synaptotagmin regulate evoked versus spontaneous release.
Nature communications - 22 Mar 2016
Bai Hua, Xue Renhao, Bao Huan, Zhang Leili, Yethiraj Arun, Cui Qiang, Chapman Edwin R
Abstract excerpt
The tandem C2-domains of synaptotagmin 1 (syt) function as Ca(2+)-binding modules that trigger exocytosis; in the absence of Ca(2+), syt inhibits spontaneous release. Here, we used proline linkers to constrain and alter the relative orientation of these C2-domains. Short poly-proline helices have a period of three, so large changes in the relative disposition of the C2-domains result from changing the length of...
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