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Article

The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme.

The Journal of biological chemistry - 4 Jun 2004

Krishnamurthy Partha, Ross Douglas D, Nakanishi Takeo, Bailey-Dell Kim, Zhou Sheng, Mercer Kelly E, Sarkadi Balazs, Sorrentino Brian P, Schuetz John D

Abstract excerpt

Our studies demonstrate that the ABC transporter and marker of stem and progenitor cells known as the breast cancer resistance protein (BCRP or ABCG2) confers a strong survival advantage under hypoxic conditions. We show that, under hypoxia, progenitor cells from Bcrp(-)/(-)mice have a reduced ability to form colonies as compared with progenitor cells from Bcrp(+/+) mice. Blocking BCRP function in Bcrp(+/+)...

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Identifiers

PMID: 15044468
DOI: 10.1074/jbc.M313599200

Genes

ABCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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