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Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells

26 May 2016

Abstract excerpt

BACKGROUND: Studies over the past decade and half have identified cancer stem cells (CSCs) to be responsible for tumorigenesis, invasion, sustenance of metastatic disease, radio- and chemo-resistance and tumor relapse. Recent reports have described the plasticity of breast CSCs (BCSCs) to shift between the epithelial and mesenchymal phenotypes via Epithelial-Mesenchymal Transition (EMT) and Mesenchymal-Epithelial...

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PMID: 27229859
DOI: 10.1186/s12885-016-2372-4

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