Article
ABCG2 (BCRP) expression in normal and malignant hematopoietic cells.
Hematological oncology - 1 Sept 2003
Abbott Brian L
Abstract excerpt
ABCG2 (BCRP) is a member of the ATP-binding cassette (ABC) family of cell surface transport proteins. ABCG2 expression occurs in a variety of normal tissues, and is relatively limited to primitive stem cells. ABCG2 expression is associated with the side population (SP) phenotype of Hoechst 33342 efflux. The substrate profile of ABCG2 includes the antineoplastic drugs primarily targeting topoisomerases, including...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
