Article
Initiation of meiotic chromosome synapsis at centromeres in budding yeast.
Genes & development - 15 Nov 2008
Tsubouchi Tomomi, Macqueen Amy J, Roeder G Shirleen
Abstract excerpt
Previous studies of synaptonemal complex assembly in budding yeast have suggested that chromosome synapsis initiates at the sites of crossing over. The data presented here, however, indicate that centromeric regions are preferred sites for synapsis initiation. At early times during meiosis in wild type, the Zip1 protein (a major building block of the synaptonemal complex) localizes specifically to centromeric...
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