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Article

Crystal structure of HEL4, a soluble, refoldable human V(H) single domain with a germ-line scaffold.

Journal of molecular biology - 2 Apr 2004

Jespers Laurent, Schon Oliver, James Leo C, Veprintsev Dmitri, Winter Greg

Abstract excerpt

The antigen binding site of antibodies usually comprises associated heavy (V(H)) and light (V(L)) chain variable domains, but in camels and llamas, the binding site frequently comprises the heavy chain variable domain only (referred to as V(HH)). In contrast to reported human V(H) domains, V(HH) domains are well expressed from bacteria and yeast, are readily purified in soluble form and refold reversibly after...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15033359
DOI: 10.1016/j.jmb.2004.02.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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