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Article

Solubility and stability engineering of human VH domains.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Kim Dae Young, Ding Wen, Tanha Jamshid

Abstract excerpt

Solubility and stability are amongst the factors contributing to the therapeutic efficacy of biologics. Human antibody heavy chain variable domains, VHs, are one class of biologics; improving VH biophysical properties is the focus of significant protein engineering efforts. Here, we describe an efficacy engineering approach which involves the introduction of a disulfide linkage in the VH core and which improves...

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Identifiers

PMID: 22886262
DOI: 10.1007/978-1-61779-968-6_21

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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