Article
Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1.
BMC molecular biology - 22 May 2007
Goodliffe Julie M, Cole Michael D, Wieschaus Eric
Abstract excerpt
BACKGROUND: The Myc oncoprotein is a transcriptional regulator whose function is essential for normal development. Myc is capable of binding to 10% of the mammalian genome, and it is unclear how a developing embryo controls the DNA binding of its abundant Myc proteins in order to avoid Myc's potential for inducing tumorigenesis. RESULTS: To identify chromatin binding proteins with a potential role in controlling...
Topics
- Animals
- Chromatin Immunoprecipitation
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Embryo, Nonmammalian
- Gene Expression Regulation, Developmental
- Mutation
- Oligonucleotide Array Sequence Analysis
- Polycomb Repressive Complex 1