Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1.

BMC molecular biology - 22 May 2007

Goodliffe Julie M, Cole Michael D, Wieschaus Eric

Abstract excerpt

BACKGROUND: The Myc oncoprotein is a transcriptional regulator whose function is essential for normal development. Myc is capable of binding to 10% of the mammalian genome, and it is unclear how a developing embryo controls the DNA binding of its abundant Myc proteins in order to avoid Myc's potential for inducing tumorigenesis. RESULTS: To identify chromatin binding proteins with a potential role in controlling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to Drosophila melanogaster
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to Gene Expression Regulation, Developmental

Share to Mutation

Share to Transcription Factors

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 17519021
DOI: 10.1186/1471-2199-8-40
PMCID: PMC1887537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1.PMID 17519021Read ↗

The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins.Semantic proximity Read ↗

Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila.Semantic proximity Read ↗

Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc.Semantic proximity Read ↗

Functional dissection of the ash2 and ash1 transcriptomes provides insights into the transcriptional basis of wing phenotypes and reveals conserved protein interactions.Semantic proximity Read ↗

Genome-wide binding of Multiple ankyrin repeats single KH domain reveals its role in maintenance of gene activation by trithorax group proteins in <i>Drosophila</i>Semantic proximity Read ↗

Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs.Semantic proximity Read ↗

A comprehensive HA-tagged PRC1 toolkit enables standardized chromatin profiling and proteomic analysis in Drosophila melanogasterSemantic proximity Read ↗

A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes.Semantic proximity Read ↗

From genetics to epigenetics: the tale of Polycomb group and trithorax group genes.Semantic proximity Read ↗

The Drosophila trithorax gene encodes a chromosomal protein and directly regulates the region-specific homeotic gene fork head.Semantic proximity Read ↗

Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1.Semantic proximity Read ↗

Evidence for dual roles of histone H3 lysine 4 in antagonizing Polycomb group function and promoting target gene expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.