Article
Mice with deletion of the mitochondrial glycerol-3-phosphate dehydrogenase gene exhibit a thrifty phenotype: effect of gender.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jul 2004
Alfadda Assim, DosSantos Rosangela A, Stepanyan Zaruhi, Marrif Husnia, Silva J Enrique
Abstract excerpt
To define the role of mitochondrial glycerol-3-phosphate dehydrogenase (mGPD; EC 1.1.99.5) in energy balance and intermediary metabolism, we studied transgenic mice not expressing mGPD (mGPD-/-). These mice had approximately 14% lower blood glucose; approximately 50% higher serum glycerol; approximately 80% higher serum triglycerides; and at thermoneutrality, their energy expenditure (Qo(2)) was 15% lower than in...
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