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Article

In vivo evaluation of GG2-GG1/A2 element activity in the insulin promoter region using the CRISPR-Cas9 system.

Scientific reports - 13 Oct 2021

Noguchi Hirofumi, Miyagi-Shiohira Chika, Kinjo Takao, Saitoh Issei, Watanabe Masami

Abstract excerpt

The insulin promoter is regulated by ubiquitous as well as pancreatic β-cell-specific transcription factors. In the insulin promoter, GG2-GG1/A2-C1 (bases - 149 to - 116 in the human insulin promoter) play important roles in regulating β-cell-specific expression of the insulin gene. However, these events were identified through in vitro studies, and we are unaware of comparable in vivo studies. In this study, we...

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Identifiers

PMID: 34645928
DOI: 10.1038/s41598-021-99808-6
PMCID: PMC8514523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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