Article
Regulation of endocytosis by the small GTP-ase rab5.
Cytotechnology - 1 Jan 1993
Zerial M
Abstract excerpt
Rab5 is a small GTPase associated with the plasma membrane and the early endosomes. Expression of wild type rab5 and a mutant protein defective in GTP-binding in BHK cells led to alterations in the rate of endocytosis and in the morphology of endocytic organelles. The results obtained suggest that rab5 is a rate limiting GTPase that regulate the kinetics of both lateral fusion of early endosomes and fusion of...
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