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Article

The regulation of somatic hypermutation.

Current opinion in immunology - 1 Apr 2004

Besmer Eva, Gourzi Polyxeni, Papavasiliou F Nina

Abstract excerpt

Somatic hypermutation and class switch recombination cause genetic alterations in immunoglobulin (Ig) genes, which underlie the generation of the secondary antibody repertoire in B lymphocytes. Both processes require activation-induced cytidine deaminase (AID), whose mechanism of action in not yet known in detail, but which mediates the accumulation of point mutations in the Ig locus. This highly mutagenic...

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Source

Identifiers

PMID: 15023419
DOI: 10.1016/j.coi.2004.01.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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