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Article

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

17 Dec 2018

Abstract excerpt

Systematic exploration of cancer cell vulnerabilities can inform the development of novel cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we identify adenosine deaminase acting on RNA (ADAR or ADAR1) as an essential gene for the survival of a subset of cancer cell lines. ADAR1-dependent cell lines display increased expression of interferon-stimulated genes. Activation of...

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PMID: 30575730
DOI: 10.1038/s41467-018-07824-4

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