The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae.

doi:10.1074/jbc.M400272200

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Article

The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae.

The Journal of biological chemistry - 14 May 2004

Budovskaya Yelena V, Stephan Joseph S, Reggiori Fulvio, Klionsky Daniel J, Herman Paul K

Abstract excerpt

When faced with nutrient deprivation, Saccharomyces cerevisiae cells enter into a nondividing resting state, known as stationary phase. The Ras/PKA (cAMP-dependent protein kinase) signaling pathway plays an important role in regulating the entry into this resting state and the subsequent survival of stationary phase cells. The survival of these resting cells is also dependent upon autophagy, a membrane...

Topics

Autophagy
Cyclic AMP-Dependent Protein Kinases
Genotype
Saccharomyces cerevisiae
Signal Transduction
ras Proteins

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Identifiers

PMID: 15016820
DOI: 10.1074/jbc.M400272200
PMCID: PMC1705971

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