Article
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast.
The Journal of biological chemistry - 13 Feb 1998
Noda T, Ohsumi Y
Abstract excerpt
Autophagy is a bulk protein degradation process that is induced by starvation. The control mechanism for induction of autophagy is not well understood. We found that Tor, a phosphatidylinositol kinase homologue, is involved in the control of autophagy in the yeast, Saccharomyces cerevisiae. When rapamycin, an inhibitor of Tor function, is added, autophagy is induced even in cells growing in nutrient-rich medium....
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