Article
The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy.
Proceedings of the National Academy of Sciences of the United States of America - 6 Oct 2009
Stephan Joseph S, Yeh Yuh-Ying, Ramachandran Vidhya, Deminoff Stephen J, Herman Paul K
Abstract excerpt
Macroautophagy (or autophagy) is a conserved degradative pathway that has been implicated in a number of biological processes, including organismal aging, innate immunity, and the progression of human cancers. This pathway was initially identified as a cellular response to nutrient deprivation and is essential for cell survival during these periods of starvation. Autophagy is highly regulated and is under the...
Topics
- Adaptor Proteins, Signal Transducing
- Autophagy
- Autophagy-Related Proteins
- Blotting, Western
- Cyclic AMP-Dependent Protein Kinases
- Immunoprecipitation
- Luminescent Proteins
- Microscopy, Fluorescence
- Models, Biological
- Mutation
- Phosphorylation
- Protein Kinases