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Article

High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.

Cancer science - 1 Jun 2005

Tsuda Hiroyuki, Fukamachi Katsumi, Ohshima Yutaka, Ueda Shinobu, Matsuoka Yoichiro, Hamaguchi Tetsuya, Ohnishi Takamasa, Takasuka Nobuo, Naito Akihiro

Abstract excerpt

Transgenic animals carrying human c-Ha-ras proto-oncogene, v-Ha-ras transgenic mice, pim-1 transgenic mice and several knockout mice deficient of tumor suppressor genes, such as p53, have been shown to exhibit increased carcinogen susceptibility. As a result, studies into practical application and medium-term screening of environmental carcinogens are under way. Given the advantages of rat models characterized by...

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Identifiers

PMID: 15958052
DOI: 10.1111/j.1349-7006.2005.00056.x
PMCID: PMC11158793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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