Article
Linkage analysis of SLE susceptibility: confirmation of SLER1 at 5p15.3.
Genes and immunity - 1 May 2004
Nath S K, Namjou B, Garriott C P, Frank S, Joslin P A, Kilpatrick J, Kelly J A, Harley J B
Abstract excerpt
We detected a novel susceptibility gene, SLER1, for systemic lupus erythematosus (SLE) at 5p15.3.(1) This finding was based on a selected subgroup of SLE families, where two or more family members have had alleged rheumatoid arthritis (SLE-RA). The main objective of this study was to replicate the linkage at 5p15.3 based on an independent data set of 88 SLE-RA families. Heterogeneity in the genetic model led us...
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