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Systemic lupus erythematosus genome scan: support for linkage at 1q23, 2q33, 16q12-13, and 17q21-23 and novel evidence at 3p24, 10q23-24, 13q32, and 18q22-23.

Arthritis and rheumatism - 1 Oct 2004

Cantor Rita M, Yuan Jinying, Napier Susan, Kono Naoko, Grossman Jennifer M, Hahn Bevra H, Tsao Betty P

Abstract excerpt

OBJECTIVE: To identify chromosome regions likely to harbor genes that predispose to the development of systemic lupus erythematosus (SLE) by analyzing a full genome scan in nuclear families ascertained for siblings with SLE. METHODS: Approximately 400 multiallelic markers spaced an average of 10 cM apart were genotyped in a multiethnic panel of 238 individuals from 62 multiplex SLE families having 88 affected...

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PMID: 15476245
DOI: 10.1002/art.20511

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