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Article

Genome screening in human systemic lupus erythematosus: results from a second Minnesota cohort and combined analyses of 187 sib-pair families.

American journal of human genetics - 1 Feb 2000

Gaffney P M, Ortmann W A, Selby S A, Shark K B, Ockenden T C, Rohlf K E, Walgrave N L, Boyum W P, Malmgren M L, Miller M E, Kearns G M, Messner R P, King R A, Rich S S, Behrens T W

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a loss of immunologic tolerance to a multitude of self-antigens. Epidemiological data suggest an important role for genes in the etiology of lupus, and previous genetic studies have implicated the HLA locus, complement genes, and low-affinity IgG (Fcgamma) receptors in SLE pathogenesis. In an effort to identify new susceptibility loci...

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Identifiers

PMID: 10677315
DOI: 10.1086/302767
PMCID: PMC1288108

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