Article
A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families.
Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 1998
Gaffney P M, Kearns G M, Shark K B, Ortmann W A, Selby S A, Malmgren M L, Rohlf K E, Ockenden T C, Messner R P, King R A, Rich S S, Behrens T W
Abstract excerpt
Systemic lupus erythematosus (SLE) is an autoimmune multisystem inflammatory disease characterized by the production of pathogenic autoantibodies. Previous genetic studies have suggested associations with HLA Class II alleles, complement gene deficiencies, and Fc receptor polymorphisms; however, it is likely that other genes contribute to SLE susceptibility and pathogenesis. Here, we report the results of a...
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