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Article

Genome scan of human systemic lupus erythematosus by regression modeling: evidence of linkage and epistasis at 4p16-15.2.

American journal of human genetics - 1 Dec 2000

Gray-McGuire C, Moser K L, Gaffney P M, Kelly J, Yu H, Olson J M, Jedrey C M, Jacobs K B, Kimberly R P, Neas B R, Rich S S, Behrens T W, Harley J B

Abstract excerpt

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder involving at least hormonal, environmental, and genetic factors. Familial aggregation, a 2%-3% sibling recurrence rate, monozygotic twin concordance >20%, association with several candidate genes, as well as the results of five genome scans support a genetic component. We present here the results of a genome scan of 126 pedigrees multiplex for...

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Identifiers

PMID: 11078476
DOI: 10.1086/316891
PMCID: PMC1287923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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