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Article

TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis, and resistance to arachidonate-induced death.

Blood - 1 Jul 2004

Yu I-Shing, Lin Shu-Rung, Huang Chin-Chin, Tseng Hui-Yu, Huang Pei-Hsing, Shi Guey-Yueh, Wu Hua-Lin, Tang Chi-Lu, Chu Pao-Hsien, Wang Lee-Ho, Wu Kenneth K, Lin Shu-Wha

Abstract excerpt

Besides its well-recognized role in hemostasis and thrombosis, thromboxane A(2) synthase (TXAS) is proposed to be involved in thrombopoiesis and lymphocyte differentiation. To evaluate its various physiologic roles, we generated TXAS-deleted mice by gene targeting. TXAS(-/-) mice had normal bone marrow megakaryocytes, normal blood platelet counts, and normal CD4 and CD8 lymphocyte counts in thymus and spleen....

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Source

Identifiers

PMID: 15010374
DOI: 10.1182/blood-2003-10-3661

Genes

PGD
PGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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