Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins.

doi:10.1016/j.nbd.2009.07.023

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Article

Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins.

Neurobiology of disease - 1 Nov 2009

Yang Lichuan, Shi Qingli, Ho Daniel J, Starkov Anatoly A, Wille Elizabeth J, Xu Hui, Chen H L, Zhang Steven, Stack Cliona M, Calingasan Noel Y, Gibson Gary E, Beal M Flint

Abstract excerpt

The activity of a key mitochondrial tricarboxylic acid cycle enzyme, alpha-ketoglutarate dehydrogenase complex (KGDHC), declines in many neurodegenerative diseases. KGDHC consists of three subunits. The dihydrolipoyl succinyl transferase (DLST) component is unique to KGDHC. DLST(+/-) mice showed reduced mRNA and protein levels and decreased brain mitochondrial KGDHC activity. Neurotoxic effects of mitochondrial...

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Identifiers

PMID: 19660549
DOI: 10.1016/j.nbd.2009.07.023
PMCID: PMC3605719

Genes

DLST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.