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Article

Gene editing of a human gene in yeast artificial chromosomes using modified single-stranded DNA and dual targeting.

The pharmacogenomics journal - 1 Jan 2004

van Brabant A J, Williams J K, Parekh-Olmedo H, Kmiec E B

Abstract excerpt

A single-nucleotide polymorphism (SNP) in a human gene can alter the behavior of the corresponding protein, and thereby affect an individual's response to drug therapy. Here, we describe a novel dual-targeting approach for introducing an SNP of choice into virtually any gene, through the use of m...

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Share to Chromosomes, Artificial, Yeast
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Molecular Sequence Data

Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 15007372
DOI: 10.1038/sj.tpj.6500237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15007372-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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