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Article

Killing cancer by targeting genes that cancer cells have lost: allele-specific inhibition, a novel approach to the treatment of genetic disorders.

Cellular and molecular life sciences : CMLS - 1 May 2003

Fluiter K, Housman D, Ten Asbroek A L M A, Baas F

Abstract excerpt

Oligonucleotide-based drugs are now rapidly establishing themselves as an important tool in both research and treatment of genetic disorders. In the past many problems were encountered in using antisense oligonucleotides. Our expanding knowledge and new oligonucleotide chemistries are giving us t...

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Share to Alleles
Share to Gene Targeting
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

Share to Neoplasms

Share to Oligonucleotides, Antisense

Share to Polymorphism, Single Nucleotide

Share to RNA Interference

Source

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Identifiers

PMID: 12827273
DOI: 10.1007/s00018-003-3043-6
PMCID: PMC11138713

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12827273-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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