Inactivation of Ras function by allele-specific peptide aptamers.

doi:10.1038/sj.onc.1205680

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Article

Inactivation of Ras function by allele-specific peptide aptamers.

Oncogene - 22 Aug 2002

Xu C Wilson, Luo Zhijun

Abstract excerpt

One challenge facing biology is the elucidation of the function of the estimated 30 000 human genes and their polymorphic variants. Reagents that affect the activity of specific genes will be useful in the dissection of cellular regulatory networks. Here, as a test case, we used a two-bait two-hybrid system to identify peptide aptamers that distinguish allelic forms of H-Ras. Some of these anti-Ras aptamters...

Topics

Alleles
Amino Acid Sequence
Epidermal Growth Factor
Genes, ras
Molecular Sequence Data
Peptides
Proto-Oncogene Proteins c-raf
Two-Hybrid System Techniques

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PMID: 12173045
DOI: 10.1038/sj.onc.1205680

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