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Article

No association of the 5' promoter region polymorphism of CYP17 gene with prostate cancer risk.

Prostate cancer and prostatic diseases - 1 Jan 2002

dos Santos A, Ribeiro M L, Mesquita J C, Carvalho-Salles A B, Hackel C

Abstract excerpt

CYP17 gene encodes the enzyme cytochrome p450c17alpha, which mediates two steps in the steroid biosynthesis pathway. Steroid hormones are believed to play a key role in the etiology of prostate cancer. A polymorphic T-->C transition in the 5(') promoter region of CYP17 creates an additional Sp1-type (CCACC box) promoter site (allele A2). We have evaluated the genotypic and allelic distribution of this...

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Identifiers

PMID: 15195127
DOI: 10.1038/sj.pcan.4500550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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