Article
Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study.
The Journal of allergy and clinical immunology - 1 Mar 2004
Liu Xin, Beaty Terri H, Deindl Philipp, Huang Shau-Ku, Lau Susanne, Sommerfeld Christine, Fallin M Daniele, Kao W H Linda, Wahn Ulrich, Nickel Renate
Abstract excerpt
BACKGROUND: Among many published studies of specific IgE response or atopy, only a few showed positive marginal effects for 6 potentially functional single nucleotide polymorphisms (SNPs; C-590T in the IL4 gene, C-1055T and Arg130Gln in the IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the IL4RA gene). SNPs were commonly considered individually, and therefore the true effect could be masked by other genes...
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