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Article

Atopic Dermatitis Mediates the Association Between an IL4RA Variant and Food Allergy in School-Aged Children.

The journal of allergy and clinical immunology. In practice - 1 Aug 2022

Banzon Tina M, Kelly Michael S, Bartnikas Lisa M, Sheehan William J, Cunningham Amparito, Harb Hani, Crestani Elena, Valeri Linda, Greco Kimberly F, Chatila Talal A, Phipatanakul Wanda, Lai Peggy S

Abstract excerpt

BACKGROUND: Atopic dermatitis (AD) and food allergy (FA) may share genetic risk factors. It is unknown whether genetic factors directly cause FA or are mediated through AD, as the dual-allergen hypothesis suggests. OBJECTIVE: To test the hypothesis that AD mediates the relationship between an IL-4 receptor alpha chain gene (IL4RA) variant, the human IL-4 receptor alpha chain protein-R576 polymorphism, and FA....

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Source

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Identifiers

PMID: 35589010
DOI: 10.1016/j.jaip.2022.04.042
PMCID: PMC9811396

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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