Article
Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas
1 Jan 2001
Abstract excerpt
High-risk human papillomaviruses (HPVs) have been proposed to be associated with a subset of head and neck cancers (HNSCCs). However, clear biological evidence linking HPV-mediated oncogenesis to the development of HNSCC is hardly available. An important biological mechanism underlying HPV-mediated carcinogenesis is the inactivation of p53 by the HPV E6 oncoprotein. In the present study we investigated this...
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