Article
A promotor polymorphism in the Interleukin 11 gene is associated with chronic obstructive pulmonary disease.
Electrophoresis - 1 Mar 2004
Klein Wolfram, Rohde Gernot, Arinir Umut, Hagedorn Michaela, Dürig Natascha, Schultze-Werninghaus Gerhard, Epplen Jörg T
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is a multifactorial disorder characterized by irreversible airflow obstruction due to chronic inflammation. Hence, the gene encoding the anti-inflammatory cytokine IL 11 is a good candidate for being involved in the genetic predisposition to COPD. In order to evaluate the role of the Interleukin 11 (IL 11) gene in the genetic predisposition for COPD, a dinucleotide...
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