Article
A promotor polymorphism in the Interleukin 11 gene is associated with chronic obstructive pulmonary disease.
Electrophoresis - 1 Mar 2004
Klein Wolfram, Rohde Gernot, Arinir Umut, Hagedorn Michaela, Dürig Natascha, Schultze-Werninghaus Gerhard, Epplen Jörg T
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is a multifactorial disorder characterized by irreversible airflow obstruction due to chronic inflammation. Hence, the gene encoding the anti-inflammatory cytokine IL 11 is a good candidate for being involved in the genetic predisposition to COPD. In o...
Topics
- Aged
- Alleles
- Binding Sites
- Dinucleotide Repeats
- Female
- Gene Frequency
- Genetic Linkage
- Haplotypes
- Humans
- Interleukin-11
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic
- Pulmonary Disease, Chronic Obstructive
- Smoking